Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis.
نویسندگان
چکیده
منابع مشابه
Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis.
BACKGROUND Azelastine nasal spray and oral cetirizine are selective histamine H(1)-receptor antagonists that are approved in the United States for the treatment of seasonal allergic rhinitis (SAR). OBJECTIVE The objective of the present study was to compare the efficacy and tolerability of azelastine nasal spray administered at the recommended dosage of 2 sprays per nostril twice daily with t...
متن کاملMontelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation.
BACKGROUND The aim of our study was to investigate effects of 6-week pretreatment of seasonal allergic rhinitis (AR) with cetirizine, and montelukast, alone and in combination. Antihistamine/antileukotriene treatment is effective in AR. Antihistamines may prevent AR symptoms while prophylactic activity of antileukotrienes remains unclear. METHODS Sixty AR patients, aged 18-35 years, were rand...
متن کاملComparison of nasal responsiveness to histamine, methacholine and phentolamine in allergic rhinitis patients and controls.
In a selected group of rhinitis patients with an IgE-mediated allergy to house dust mites the nasal response to insufflation of histamine chloride, methacholine and phentolamine was demonstrated to be higher than in a control group. With the methods used histamine chloride was better at discriminating between healthy subjects and patients than methacholine or phentolamine. This discrimination w...
متن کاملcomparison of loratadine and cetirizine in perennial allergic rhinitis
background: allergic rhinitis (ar) represents a global health problem, affecting 5-50% of the population worldwide and numerous classes of pharmacological agents are available for its treatment. two more popular of these drugs are loratadine and cetirizine. there are few direct comparator studies between these two drugs with inconsistent results. m aterials and methods: a randomized, double-bli...
متن کاملLocalization and Upregulation of the Nasal Histamine H1 Receptor in Perennial Allergic Rhinitis
In the present study, we have investigated the expression of histamine H1 receptor in human turbinates by RT-PCR, western blotting, and immunohistochemistry. Human turbinates were obtained by turbinectomy from 12 patients with nasal obstruction refractory to medical therapy. RT-PCR analysis of total RNA extracted from human nasal turbinate, primary cultured human nasal epithelial cells, and nas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1992
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1992.tb04065.x